Effect of Walnut Seed Skin Against Main Organ Damage Caused by Hyperlipidemia

Hyperlipidemia, manifested as hypercholesterolemia and/or hypertriglyceridemia, is a condition characterized by decrease in HDL levels with an increase one or more of plasma lipids, including triglycerides cholesterol, cholesterol esters, phospholipids, lipoproteins VLDL and LDL. It also major problem leading to obesity, stroke, myocardial infarction, atherosclerosis, type 2 diabetes, degenerative joint disease circulatory has become the most common causes morbidity mortality worldwide. Current anti-hyperlipidemic therapies mainly include statins fibrates. These drugs used firstly inhibit biosynthesis correct changed blood lipid profile. Secondly, it acts increasing clearance triglyceride-rich lipoproteins. In addition hepatotoxicity, myopathy, rhabdomyolysis some undesirable side effects during pregnancy have been reported. While these limit use hyperlipidemia, they support research medicinal plant products hypolipidemic-phyto-active compounds. The study plants useful strategy for emergence new molecules that important enhanced effect on metabolism. For this reason, current study, considering many beneficial walnuts supported literature, unused part walnut seed skin (WSS) focused on. was investigated whether ethanolic extraction (E-WSS) had protective male Wistar-Albino rats which hyperlipidemia induced. histopathological evaluation E-WSS kidney tissue, content defined GC-MS our previous performed study. analysis, concluded extract significant tissue when compared healthy control group. When final made, contribution made literature natural compound does not show toxic against hyperlipidemia.